The Female Brain is a 2017 American comedy film directed by Whitney Cummings and written by Neal Brennan and Cummings. It is based on the 2006 book The Female Brain by Louann Brizendine. The film stars Cummings, Sofía Vergara, Toby Kebbell, James Marsden, Deon Cole, Lucy Punch, Beanie Feldstein and Cecily Strong.