A Lady Takes a Chance is a 1943 American romantic comedy film directed by William A. Seiter and starring Jean Arthur and John Wayne. Written by Robert Ardrey and based on a story by Jo Swerling, the film is about a New York working girl who travels to the American West on a bus tour and meets and falls in love with a handsome rodeo cowboy. The film was produced for RKO Radio Pictures by Frank Ross, who was Arthur's husband at the time. The supporting cast features Phil Silvers, Hans Conried, Charles Winninger and Mary Field.